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We are developing both oral and a topical formulation of endoxifen. In mid we completed a Phase 1 clinical study which was conducted by a leading Clinical Research Organization in Australia. The study was a placebo-controlled, repeat dose study of 48 healthy female volunteers. Go here objectives were to assess safety, tolerability and pharmacokinetics of both formulations of endoxifen over 28 days.

All gta online casino reddit were successfully met in the topical arms of the study. The topical formulation of our proprietary endoxifen is being developed for women with a condition call mammographic breast density, or MBD, which has been shown in third-party studies to result in a higher risk of developing breast cancer.

To date, 30 U. Although oral tamoxifen has been shown to reduce MBD, the benefit-risk ratio is generally not acceptable to most physicians and their patients. In mid we completed a Phase 1, gta online casino reddit study of our proprietary topical Endoxifen.

All objectives of that study were successfully met:. The data from the Phase 1 study demonstrate the suitability of topical Endoxifen for further clinical development. We have initiated gta online casino reddit Phase 2 study of our topical endoxifen in women with MBD. The study will be conducted at Stockholm South General Hospital in Sweden and will http://sigur-ros.info/european-casino-card-games.php led by principal investigator Dr.

Per Hall, MD, Ph. The placebo-controlled, double-blinded study is expected to enroll up to subjects. The primary endpoint is MBD reduction, which will be measured after six and twelve months of dosing, as well as safety and tolerability.

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Subject to favorable results from our Phase gta online casino reddit study, we are planning to begin a Phase 2 study of oral endoxifen for these patients who are refractory to tamoxifen. We are also evaluating endoxifen in the neo-adjuvant setting, meaning it would be use to treat breast cancer before surgery to remove the cancerous tumor. We are developing our patented microcatheter technology to deliver therapeutics through the nipple directly to the site of the cancer.

The goals of this delivery method are to increase the amount of the therapy getting to the targeted area while reducing the side effects that would otherwise be caused by delivering the drug through the blood stream.

We believe our patented intraductal microcatheter technology may be useful in delivering a number of drugs directly to the breast tissue. The initial drug we are studying using our microcatheters is fulvestrant. Fulvestrant is FDA-approved for metastatic breast cancer. It is administered as a monthly intramuscular injection of gta online casino reddit injections, typically into the buttocks.

We own one issued patent gta online casino reddit several pending applications directed to the treatment of breast conditions, including cancer, by the intraductal administration of therapeutics, including fulvestrant. We are currently conducting a Phase 2 study using our microcatheter technology check this out deliver fulvestrant at Montefiore Medical Center.

This trial is a Phase 2 study in women with ductal carcinoma in situ Gta online casino reddit or Stage 1 or 2 breast cancer invasive ductal carcinoma scheduled for mastectomy or lumpectomy within 30 to 45 days. This study is assessing the safety, tolerability, cellular activity and distribution of fulvestrant when delivered directly into breast milk ducts of these patients compared to those who receive the same drug by injection.

Of the 30 patients required for full enrollment, six will receive the standard intramuscular injection of fulvestrant and 24 will receive fulvestrant with our microcatheter device. The primary endpoint of the clinical trial is to compare the safety, tolerability and distribution of fulvestrant between the two routes of administration intramuscular injection or through our microcatheters. The secondary endpoint of the study is to determine if there are changes in the expression of Ki67 as well as estrogen and progesterone receptors between a pre-fulvestrant biopsy gta online casino reddit post-fulvestrant surgical specimens.

Digital breast imaging before and after drug gta online casino reddit in both groups will also be performed to determine the effect of fulvestrant on any lesions as well as breast density of the participant. We plan to use our proprietary gta online casino reddit microcatheter technology to deliver CAR-T cells into the ducts of the breast for the potential targeted treatment of breast cancer.

We believe this method has several potential advantages: This program is in the research and development phase and has not been approved by the FDA or any other regulatory body. Http://sigur-ros.info/is-gambling-money-taxable-in-uk.php studies, and clinical studies demonstrating safety and efficacy among other things, and regulatory approvals will be required before commercialization.

Chin J Cancer Res. The T cells, which can then recognize and kill the cancer cells, are reintroduced into the patient using a microcatheter into the natural ducts of the breast. Typically, these receptors are used to graft the specificity of a monoclonal antibody gta online casino reddit a T cell, with transfer of their coding sequence facilitated by retroviral vectors. The receptors are called chimeric because they are composed of parts from different sources.

Endoxifen Endoxifen is the most active metabolite ingredient of the FDA-approved drug gta online casino reddit, which has been used since its approval in for breast cancer survivors to prevent recurrence as well as the development of new link. All objectives of that study were successfully met: There were no clinically significant safety signals and no clinically significant adverse events in participants receiving topical Endoxifen.

Topical Endoxifen was well tolerated at each dose level and for the dosing duration utilized in the study. Topical Endoxifen crossed the skin barrier when applied daily to gta online casino reddit breast, as эти slot quest games последнее by low but measurable Endoxifen blood levels detected in a dose-dependent fashion.

Microcatheter Technology We are developing our patented microcatheter technology to deliver therapeutics through the nipple directly to the site of the cancer.


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Grand Theft Auto Online is a dynamic and persistent open world for up to 30 players that begins by sharing content and mechanics with Grand Theft Auto V, but continues to expand and evolve http://sigur-ros.info/william-hill-poker-deposit-options.php content created by Rockstar and other players.

Grand Theft Auto Online will continually expand and evolve over time with gta online casino reddit constant stream of new content, creating the first ever persistent and dynamic GTA game world. I quickly became interested in future ideas and created a timeline for my predictions:.

Most people thought that this would be released with the IGG, but I think that this is so big that Rockstar will make it into it's own dlc. It fits well with the story line of the IGG. The criminals of Los Santos are extremely rich and the stock of mansions is rising. It will give the people of Los Santos a luxurious life, and the Casino will add to their large amounts of money. One reason why I think that mansions will be coming is because of the key codes found at the front of them.

They are the same key pads found at apartments, so I think that Rockstar has intentions of giving the community the ability to purchase these homes. A reason why I believe that Rockstar has been striking Youtubers posting gta online casino reddit glitches and exploits is because they're trying to prepare the economy for something like a Casino. Adding something gta online casino reddit this could be abused with money glitches and I believe Rockstar wants to prevent the Casino from just being a place for players to get unlimited money.

Now, the casino in real life Los Angeles was actually taken down recently, but Rockstar didn't just put it in GTA to be a land site. At the front of it there has been a big banner saying "Opening soon", and I believe that it will come very gta online casino reddit. If this dlc were to gta online casino reddit out it would change the idea of a dlc being new cars, guns, clothing, and its a wrap. I think the whole community would applaud Rockstar and it would bring a lot of life back in see more Online.

It would be something different. This game mode was found in the files and I believe Rockstar will add it soon. Adding to the class of Off-road vehicles will be good for the game. Maybe some new dirt bikes and monster trucks to use in a new mode which leads me to my next idea. A demo derby mode where players can have the up most fun in the Maze Bank Arena.

The interiors of the arena was actually found in the game files and I believe it will be opened up for demolition derbies. Once again Rockstar would be opening a big thing in Los Santos, and I think that the community would be extremely happy with GTA if this would occur.

As well as the surf board and the Yacht to make the oceans of Los Santos more gta online casino reddit. Valentines Day Special 2. A lot of the community has asked for this mode to return and it will finally arrive in I also think it would be awesome gta online casino reddit players could purchase the police uniform, and have the ability to purchase Police vehicles and store them in garages.

This will be so hyped up that players will be in this game mode for hours. Independence Day Special 2. This will be a satisfying update before a major dlc is released I http://sigur-ros.info/online-casinos-australia-reviews.php well over a year since the first heist update is enough time for Rockstar to be able to create 5 new heist missions.

The players of GTA can't resist the temptation of getting more tons of money from criminal activity, and they return to their old ways.

Also some new army combat air crafts and vehicles to be added. Gta online casino reddit "toys" for the wealthy population like cars, guns, and high end clothing. Rockstar could do so many things with this dlc. For example, the story best casino in the usa Franklin, Michael, and Trevor before everything happened.

Or a dlc where Franklin takes back Grove Street. A dlc introducing entirely new characters, or telling the story of a side character like Lamar. Whatever Rockstar decides on, I think it will still be epic! As well as dancing in the night club and a different style of clothes. Adding a new class of formula 1 Скажет, start a online casino вдруг and new races.

As well as racing suits and continue reading game mode. It would be one the greatest updates of GTA Online. High Life Update 2. Sports DLC -Adding new mini-game sports like basketball and sand volleyball, this would be the ultimate sporty update online slot games ra wrap up summer Also, a great feature to add is this DLC is the option to go to the weight room with Brucie and enhance your characters body type.

They could also have San Fierro in the 's, North Yankton, or introduce a totally new world. Wherever it is, it will be hyped up so much that Rockstar will gta online casino reddit some big money off of GTA 6. Starting a whole new generation. So please leave a comment on a cool idea that you have as I would love to hear it! I'm gonna be "that guy" I guess and say I can guarantee Not sure you understand how casinos work. It will not add to people's income if you do online jersey gambling new right.

You and I play poker, you bet 1, on your 2 pair. And 2 Also that is not http://sigur-ros.info/poker-bonus-deposit-awal.php poker works nor a casino. Yes there gta online casino reddit be exceptions read more winners but they will be outnumbered greatly by the majority aka losers.

Yea ik it's old but I was browsing about the new update and saw your comment and thought I'd throw gta online casino reddit 2 cents in.

Either as an add-on to Los Santos Customs, or as a separate LSC-style business, but the ability to customize the interior of your car: Man I wanted to read all that. Nice ideas and I jope that new properties are coming soon and more customization for our vehicles. Is there a http://sigur-ros.info/european-casino-games.php mode when using cop vehicles? I'd really want that. And also be able to deliver pizzas. Just simple ones I can think of.

All I want is poker, I know they'll cap how much you can win at a table like maybe 10k. But because the game is plagued with kids, I know I can win easily. Use of this site constitutes acceptance of our User Agreement and Privacy Policy. Upvoting posts that gta online casino reddit like helps more people in the community see them. Already have an account? Don't have an account?

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This name will be used to credit you for things you share on Reddit. What should we call you? Having a hard time picking a name? Here are some available suggestions. Log in or sign up in seconds. Submit a new link. Submit a new text post. Memes, "IRL", and reaction posts are okay for now. Certain types of YouTube content are disallowed - read this post for details. Inappropriate rudeness, source or racism will not gta online casino reddit tolerated.

Click here to view how to do so. Looking for players - seeking other players to play together, make machinima, crew recruitment etc. Images of gameplay or game-related content. Exhibition and discussion of user-created content such as races and deathmatches. Discussion of gameplay, gta online casino reddit features, news, speculation, and more.

Stories of in-game experiences; rants and raves. Seeking information or gta online casino reddit answers regarding game features, content, and gameplay. Opinion questions should be tagged as Discussion. Seeking help for technical or in-game issues. Tips, warnings, and factual information that players should know about. Posts with low effort titles will be removed. Inappropriately all caps titles, especially for YouTube videos, will be please click for source. Contact Rockstar gtaonline rockstargames.

This is an archived post. You won't be able to vote or comment. I quickly became interested in future ideas and created a timeline for my predictions: Ill Gotten Gains Part 2 August


The REAL Reason GTA 5's Casino Has NOT Been Opened Up In GTA Online & Why It Might NEVER Open!

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With GTA Online’s July update, Rockstar has added a new mode that seems partially inspired by Battlegrounds, some new (and REALLY expensive) skins, and a super car.
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